Consumer's Guide to PhosphatidylSerine

PhosphatidylSerine (PS) has proven to be a safe and effective therapeutic agent in treating memory deficit disorders and for improving other higher brain functions. Here is the information you need to see how this plant-derived substance can improve the quality of your life.

What can Phosphatidylserine (PS) do for Me?

PET image of a 59-year-old female's brain. The color scale indicates regional glucose metabolism at three brain levels, red is most intense and blue is least. Upper: before Flavay Plus; Lower: after Flavay Plus daily for three weeks.

PS in Flavay Plus® increases metabolism throughout your entire brain.

(Above:) PET imaging of the brain of a 59-year-old woman. The color scale indicates regional glucose metabolism at three brain levels, red is most intense and blue is least. UPPER: before PS; LOWER: after taking 500 MG PS daily for three weeks. Metabolism is increased in almost all brain regions. (109)

Over 3,000 published research papers and more than 60 clinical trials have established that phosphatidylserine in Flavay Plus® can rejuvenate your brain cell membranes and thereby:

  • strengthen your memory,
  • increase vigilance and attention,
  • boost learning,
  • increase mental acuity,
  • intensify your concentration,
  • relieve depression and improve mood,
  • inhibit exercise and stress induced increases in cortisol,
  • decrease stress—for both young and old.

Turn Back Brain-Aging with Phosphatidylserine (PS)

Chart: Years of improvement following 12 weeks of 300 mg of phosphatidylserine in Flavay Plus per day. 13.9 Years: Remembering names after introduction. 11.6 Years: Learning and Remembering written information. 7.4 Years: Recognizing a previously seen person. 3.9 Years: Dialing a ten-digit phone number from Memory.

PS in Flavay Plus® may turn back the aging process in your brain. (168)

Human clinical studies show phosphatidylserine (PS) may assist against the symptoms of dementia and Age-Associated Memory Impairment (AAMI), including reducing the risk of dementia and cognitive dysfunction.

A reversal of brain aging of nearly 14 years was found after 12 weeks of supplementation with 300 mg per day of phosphatidylserine (in Flavay Plus®). Improvements were found in learning and remembering written information, remembering names and recognizing people, and memory of numbers. (168)

Children and young adults also get results in maintaining a sharp mind and controlling stress with PS. Studies show students experience improved learning abilities and performance. Placebo-controlled and double-blind trials show that young university students experience significantly less stress from tests, stay more clear-headed and composed, and keep a more stable mood when taking PS in Flavay Plus® (191)

How Does PhosphatidylSerine Work?

Chart of phosphatidylserine (phosphatidyl serine) supplementation in young versus old impaired versus old impaired with phosphatidylserine shows that phosphatidylserine supplementation promotes the synthesis and release of the essential brain transmitter acetylcholine, essential to memory.

PS in Flavay Plus® restores your brain's supply and output of acetylcholine— neurotransmitter essential to memory. (127)

Change the way you grow older by recharging your memory for the many years ahead.

Phosphatidylserine enables your brain cells to metabolize glucose and to release and bind with neurotransmitters, all of which is important to learning, memory and other cognitive functions.

Phosphatidylserine increases communication between cells in your brain by increasing the number of membrane receptor sites for receiving messages. Phosphatidylserine modulates the fluidity of cell membranes—essential to your brain cells' ability to send and receive chemical communication.

Scientific studies demonstrate that phosphatidylserine restores the brain's supply and output of acetylcholine, the neurotransmitter so important to memory, and so may turn back the clock in an aging brain.

Chart of phosphatidylserine (phosphatidyl serine) supplementation shows phosphatidylserine inhibits stress- induced and exercise-induced increases in cortisol.

PS in Flavay Plus® restores your brain's supply and output of dopamine—essential to memory, attention and problem-solving. (128-133)

Phosphatidylserine can increase the availability of endogenous (that which is created within your cells) choline for de novo synthesis and release (while similar treatments with phosphatidylcholine had no effect).

Phosphatidylserine also stimulates your brain to produce dopamine and this is likely why patients diagnosed with clinical depression have shown marked improvement in their symptoms as a result of taking phosphatidylserine daily. Reduced dopamine levels are also thought to contribute to attention deficit disorder and this natural substance has proven to be an effective therapeutic agent for ADD and ADHD.

Chart of phosphatidylserine (phosphatidyl serine) supplementation shows phosphatidylserine inhibits stress- induced and exercise-induced increases in cortisol.

PS in Flavay Plus® inhibits stress- and exercise-induced increases in Cortisol. (134)

Studies examining athletes involved in cycling, weight training and endurance running show that phosphatidylserine can speed recovery, prevent muscle soreness and help athletes to feel their best during the rigors of training.

We also know that phosphatidylserine is important in bone matrix formation, testicular function, beat coordination of the heart, hormone secretion by the adrenal glands and cell repair and removal by the immune system.

Modern science has only begun to understand how important phosphatidylserine is to our bodies. After all, it's present in every type of cell in our body and the membrane proteins that it activates are important in all cells. Top

Why Do I Need More PhosphatidylSerine?

Phosphatidylserine levels in brain membranes are low when diets are deficient in omega-3 fatty acids.
(169, 206, 207)

Your body cannot produce phosphatidylserine in sufficient amounts when under stress, when aged, or when lacking in necessary enzymes and metabolic cofactors.

Because of stress, aging, and our modern eating habits and food-production methods.

Stress: Like burning a candle burning at both ends, stress increases the demand for phosphatidylserine and depletes your phosphatidylserine levels at the same time.

Aging: The elderly particularly benefit from taking phosphatidyl serine. While aging increases our brain's need for phosphatidylserine it also creates digestive and metabolic inefficiency so that it's simply not possible to get enough phosphatidylserine in your diet. Considerable research has proven that phosphatidylserine improves age-associated memory impairment and continued use prevents age-related decay of brain functions.

Dietary Undersupply of Phosphatidylserine. Chart of changes in phosphatidylserine consumption: Today's typical diet: 130 mg; 1980s typical diet: 250 mg; Diet rich in meat and fish: 180 mg; Low fat diet: 100 mg; Vegetarian diet: less than 50 mg.
(Above:) Changes in daily phosphatidylserine (PS) consumption. (135)

Modern Diets: Modern low-fat and low-cholesterol diets lack up to 150 mg per day of dietary phosphatidylserine. A vegetarian diet may undersupply as much as 200 to 250 mg per day. Other eating styles also create a demand for more phosphatidyl serine. For example, a diet deficient in omega-3 fatty acids may reduce the amount of phosphatidylserine in the brain by 28% and thereby impair your brain's ability to form, store, process and remember.

Modern Food Production: To make matters worse, modern industrial production of fats and oils decreases all of the natural phospholipids—including phosphatidylserine. Top

One or two words: Phosphatidylserine or Phosphatidyl Serine?

Both ways are correct. While the term appears as one word in scientific journals, the marketplace sometimes splits the awkward name into two. Top

What is Phosphatidylserine (PS)?

Phosphatidylserine includes amino and fatty acids such as docosahexaenoic acid (DHA). The molecular structure of phosphatidylserine molecule with docosahexaenoic acid (DHA) and linoleic acid (LA) tails

Phosphatidylserine is a phospholipid vital to your brain cells. Phospholipids are molecules containing both amino and fatty acids found in every cell membrane within our bodies. The fatty acids include omega-3 and omega-6 fatty acid molecules—essential for life.

Actually, phosphatidylserine is universally present in living things from the most simple to the most complex. It is present in every one of our cells. Phosphatidylserine has many known functions throughout all of our tissues and organs, but is most important as the key building block for the billions of cells that make up our brain.

First isolated in 1942, phosphatidylserine is now available as a dietary supplement derived from soy lecithin. Top

Is Phosphatidylserine Safe?

Flavay Plus PhosphatidylSerineNON-GMO

Flavay Plus® includes phosphatidylserine extracted from soy which is confirmed non-GMO. The phosphatidylserine in Flavay Plus® was the subject of many human clinical trials regarding memory loss, mood, cognitive performance and learning ability.

The use of phosphatidylserine in Flavay Plus® is well validated through clinical research and proven safe in standard toxicology tests.

The large number of human studies conducted on phosphatidylserine in Flavay Plus® produced a flawless safety record. First, it has proven compatible with a wide array of medications including: antacids, anti-hypertensives, anti-inflammatories, antiulcer and mucolytic agents, diuretics, antithrombotics, hypoglycemics, antiarrthymics, insulin, calcium channel blockers, calcitonin, chemotherapy drugs and other prescription medications. Second, phosphatidylserine is well tolerated by elderly patients with chronic diseases such as cerebrovascular, artery and vein disorders, heart diseases, high blood pressure, diabetes, lung diseases, digestive system diseases and arthritis.

Interestingly, clinical researchers found phosphatidylserine lowered uric acid levels and liver SGPT in their elderly patients—which can signify improved liver health.Top

Phosphorylated vs. Phosphatidyl

Phosphatidyl serine's tails of amino and fatty acids, the extra negative charge on its head piece and unique conformation are essential to its specific actions. The molecular structure of phosphatidylserine molecule with docosahexaenoic acid (DHA) and linoleic acid (LA) tails

A phosphorylated serine is available as a dietary supplement but does not substitute for phosphatidyl serine (PS), despite the claims of its manufacturer. Though it resembles the head piece, phosphorylated serine is different—it is not a phospholipid and does not work like PS does.

Consumers report phosphorylated serine can cause highly uncomfortable adverse reactions. Be sure you get the real thing. Top

Authentic vs. "Borrowed" Science

Proven in clinical trials: phosphatidylserine in Flavay Plus® and Flavay® (free-radical scavenger)

Flavay Plus® contains all the essential antioxidants and their co-factor nutrients in one convenient and cost-effective capsule.

Flavay Plus PhosphatidylSerine

Not all phosphatidylserine products are equal. The marketplace is full of inferior variations of scientifically proven natural products. Those who are looking for a product that will produce the proven results and not just “claimed” or “implied” results want authentic products proven in scientific research.


Consumers want phosphatidylserine proven safe and effective.

Flavay Plus® includes phosphatidylserine extracted from soy which is confirmed non-GMO.

Who Needs Phosphatidylserine?



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“I know taking vitamins is good for you but this is much more than that. Because of taking Flavay® and Flavay Plus® I experience substantial improvement in mental sharpness, acuity and in the ability to react quickly and stay on top of situations while auto racing.”

“My psychologist husband told me that the difference in my behavior and focus is huge since taking Flavay® and Flavay Plus®. I am definitely ADD but was never diagnosed as a child. He is amazed at the changes in me, as am I.”
Ms. Danielle S.

“My son was born with a cleft palate and learning disabilities. I am no believer in nutrients but Flavay Plus® is helping my son to calm down and stay on task. I recently ran out and my son told me that not taking Flavay Plus® makes me act crazy, so I know he can tell the difference.”
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“I started taking Flavay® and Flavay Plus® for depression in January of this year. I'm very satisfied to have no withdrawal periods and no depression. I know it works because I stopped taking the products and my husband said he could tell the difference, that I wasn't 'as nice a person' when I didn't take Flavay® and Flavay Plus®. And I could tell, too. So I started taking them again.”
—Ms. E. R.

“I gave my son 2 capsules of Flavay Plus® this morning before school and I took 2 capsules myself. A few hours into the school day, my son's teacher sent me an email saying that my son is like a new child, focused and alert. She wanted to know what happened. I emailed her back about Flavay Plus®. No one told me to expect an email from the teacher on the first day of taking Flavay Plus®!

“My husband is a medical doctor. He had cautioned me not to get excited when ordering Flavay Plus®, saying ‘sometimes they make up those testimonials.’ So he liked the email from the teacher. I told him: ‘And you know what, I feel more focused myself, more able to handle [things].’”
—Ms. C.L.

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—Mr. R. K.

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—Ms. L. M.

My son says he can feel a difference in his concentration when he hasn't taken his Flavay® and Flavay Plus® so I'm ordering a supply before he runs out. Also, his acne cleared up and we weren't even using these products for that purpose.”
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—Ms. Y. K.

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Available Online:

Confirmed NON-GMO

Flavay Plus PhosphatidylSerine
Buy Now

Call: 1-800-200-1203

We gladly accept the following
major credit cards:
Visa, MasterCard, Discover, American Express

NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.