PhosphatidylSerine Slows or Even Reverses Age-Related Memory Loss and Other Cognitive Functions

Phosphatidylserine in Flavay Plus® can revitalize the declining brain.

Double-blind studies involving more than 1,000 people show that phosphatidylserine can be an effective for Alzheimer’s and other forms of dementia.

Well-designed, randomized controlled clinical trials show phosphatidylserine can partially restore memory and other higher brain functions that have been lost and revitalize the declining brain.

The largest of these studies followed 494 elderly subjects in northeastern Italy over a course of 6 months. All suffered from moderate to severe mental decline, as measured by standard tests. Treatment consisted of either 300 mg daily of phosphatidylserine or placebo. The group that took phosphatidylserine did significantly better in both behavior and mental function than the placebo group. Symptoms of depression also improved. ₍₁₁₄₎

These results agree with numerous other smaller double-blind studies involving a total of more than 500 people with Alzheimer’s, and other types of age-related dementia, who significantly improved by taking phosphatidylserine. _{(119,123,219,220,222-225)}

Phosphatidylserine in Flavay Plus® is shown to improve age-associated memory impairment and continued use prevents age-related decay of brain functions.

Double-Blind, Placebo-Controlled, Crossover Studies

Conclusions about Phosphatidylserine	Methods	Population	Dose	Duration	Study
Statistically significant behavioral improvement in both scales	Crichton and Peri geriatric rating scales	35 hospitalized senile demented patients, ages 65-91	300mg daily	6 weeks randomized, placebo-controlled, double-blinded and three weeks follow-up	Delwaide et al., 1986 ₍₂₁₉₎
	Crichton and Peri geriatric rating scales	35 hospitalized senile demented patients, ages 65-91	control: placebo		Delwaide et al., 1986 ₍₂₁₉₎
Beneficial for cognitive effects	Plutchik Geriatric Rating Scale	87 subjects with moderate cognitive deterioration, ages 55-80	300mg daily	8 weeks randomized, placebo-controlled, double-blinded and four weeks follow-up	Palmieri et al., 1987 ₍₂₂₀₎
Beneficial for cognitive effects	Plutchik Geriatric Rating Scale		control: placebo		Palmieri et al., 1987 ₍₂₂₀₎
Improved discrimination	Brain physiology (EEG)	39 elderly subjects with arteriosclerotic encephalopathy, ages 55+	300mg daily	12 weeks placebo-controlled, double-blinded and four weeks follow-up	Ransmayr et al., 1987 ₍₂₂₁₎
Improved discrimination	Brain physiology (EEG)		control: placebo		Ransmayr et al., 1987 ₍₂₂₁₎
Significant improvement (p<0.05)	The Set Test (Isaacs & Akhtar) and parameters like daily living, information, personal memory, non-personal memory	142 subjects with Alzheimer’s disease, ages 40-80	200mg daily	12 weeks placebo-controlled, double-blinded with 12- and 24-weeks follow-up	Amaducci et al., 1988 ₍₂₂₂₎
Significant improvement (p<0.05)		142 subjects with Alzheimer’s disease, ages 40-80	control: placebo		Amaducci et al., 1988 ₍₂₂₂₎
Improvement in cognitive impairment	Learning and memory tasks	51 subjects with Alzheimer’s disease, ages 55-80	300mg daily	12 weeks placebo-controlled, double-blinded	Crook et al., 1992 ₍₂₂₃₎
Improvement in cognitive impairment	Learning and memory tasks	51 subjects with Alzheimer’s disease, ages 55-80	control: placebo	12 weeks placebo-controlled, double-blinded	Crook et al., 1992 ₍₂₂₃₎
Statistically significant improvements	Plutchik Geriatric Rating Scale and Buschke Selective Reminding Test	425 geriatric patients with moderate to severe cognitive decline, ages 65-93	300mg daily	24 weeks placebo-controlled, double-blinded	Cenacchi et al., 1993 ₍₁₁₄₎
Statistically significant improvements			control: placebo	24 weeks placebo-controlled, double-blinded	Cenacchi et al., 1993 ₍₁₁₄₎

REFERENCES
- 114. Cenacchi T., et al. Cognitive decline in the elderly: A double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging, 5: 123–133, 1993.
- 119. Funfgeld, E.W., Baggen, M., Nedwidek, P., Richstein, B., Mistlberger, G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer’s type (SDAT). Prog Clin Biol Res, 317:1235-46, 1989.
- 123. Engel R.R., Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol 1992 Jun;2(2):149-55.
- 219. Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand. 1986 Feb;73(2):136-40.
- 220. Palmieri G, Palmieri R, Inzoli MR, et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J . 1987;24:73-83.
- 221. Ransmayr G, Ploerer S, Gerstenbrand F, Bauer G. Double-blind, placebo-controlled trial of phosphatidylserine in patients with arteriosclerotic encephalopathy. Clinical Trials Journal 1987;24:62-72.
- 222. Amaducci L. Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull. 1:130-4, 1988.
- 223. Crook T, Petrie W, Wells C, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull. 1992;28:61-66.
- 224. Nerozzi D, Aceti F, Melia E, et al. Phosphatidylserine and memory disorders in the aged [English abstract]. Clin Ther. 120:399-404, 1987.
- 225. Villardita C, Grioli S, Salmeri G, et al. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J. 1987;24:84-93.

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PhosphatidylSerine Slows or Even Reverses Age-Related Memory Loss and Other Cognitive Functions

Phosphatidylserine in Flavay Plus® can revitalize the declining brain.

Phosphatidylserine in Flavay Plus® is shown to improve age-associated memory impairment and continued use prevents age-related decay of brain functions.

Double-Blind, Placebo-Controlled, Crossover Studies

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