Dietary intake of phosphatidylserine is essential.
Phosphatidylserine supplementation has proven to restore activity of phosphatidylserine in
brain cell membranes, the chemical interaction and transfer of electrical impulses between
at both the sending and receiving ends. Thus, new information can more easily carve a new pattern and
memories are reinvigorated. Dietary intake of phosphatidylserine is essential because your body cannot synthesize
the fatty molecule de novo. (209)
Clinical data accumulated from over 20 years of controlled testing, including at least 21 double-blind
clinical trials, shows phosphatidylserine benefits practically all higher functions of the brain.(110, 211, 212)
Research shows an increase in phosphatidylserine may help improve children’s learning abilities and behavior.
Phosphatidylserine helps normalize brain biochemistry and physiology at every level.
Improves memory, learning and other cognitive functions in people
who are substantially impaired.
Improve depression and ease anxiety in people of all ages.
Help in coping with stress, both physical and emotional.
Potential to help children with attention and behavior
Improve activities of daily living and other quality of life for
people who suffer more severe memory loss.
As a dietary supplement, very well tolerated with virtually no
Maintaining brain levels of phosphatidylserine is associated to normal and efficient signal transduction processes, efficient glucose metabolism and healthy cognitive and mental functions. (291,336,337)
Why Isn't Diet Enough?
Because of stress, aging, modern eating habits and food-production methods.
ABOVE: Changes in our Western diet have resulted in a significant decrease in phosphatidylserine consumption in recent years, including rejection of fat, innards, organ meats and poultry skin (e.g., low-fat, low-cholesterol, and reduced-meat diets). (135)
Modern Diets: Modern low-fat and low-cholesterol diets lack up to 150 mg per day of
dietary phosphatidylserine. A vegetarian diet may undersupply as much as 200 to 250 mg per day. Other eating
styles also create a demand for more phosphatidylserine. For example, a diet deficient in omega-3 fatty
acids may reduce the amount of phosphatidylserine in the brain by 28% and thereby impair your brain’s
ability to form, store, process and remember. (135)
Modern Food Production: To make matters worse, modern industrial production of fats and
oils decreases all of the natural phospholipids—including phosphatidylserine. (135)
Stress: Like burning a candle burning at both ends, stress increases the demand for
phosphatidylserine and depletes your phosphatidylserine levels at the same time. (128-133)
Aging: The elderly particularly benefit from taking phosphatidylserine. While aging
increases our brain’s need for phosphatidylserine it also creates digestive and metabolic inefficiency so
that it’s simply not possible to get enough phosphatidylserine in diet. Considerable research proves
that phosphatidylserine improves age-associated memory impairment and continued use prevents age-related
decay of brain functions. (126, 168)
Restores Neurotransmitters— Activity, Supply and Output
Phosphatidylserine enables your brain cells to metabolize glucose and to release and bind with
neurotransmitters, all of which is important to learning, memory and other cognitive functions. (127)
Phosphatidylserine increases communication between brain cells by increasing the number of membrane
receptor sites for receiving messages. Phosphatidylserine modulates the fluidity of cell membranes—essential
to your brain cells' ability to send and receive chemical communication. (14)
Phosphatidylserine in Flavay Plus® replenishes ChAT-positive cells, thereby promoting the synthesis and release of acetylcholine— neurotransmitter essential to memory, cognition, sleep and neuromuscular control. Acetylcholine decline coincides with advancing age and is a hallmark of neurodegenerative disease. (127,330)
Restores Supply and Output of Acetylcholine
Phosphatidylserine (PS) in Flavay Plus® restores the availability of endogenous choline for de novo synthesis and release, (128-131) while similar use of phosphatidylcholine (PC) had no effect. (132)
Studies demonstrate phosphatidylserine restores the brain’s supply and output of
acetylcholine, the neurotransmitter important to memory, and so may
turn back the clock in an aging brain. (126, 127, 168)
Phosphatidylserine restores acetylcholine release by maintaining an adequate acetylcholine supply. Phosphatidylserine can increase the availability of endogenous choline for de novo synthesis and release (128-131), while similar use of phosphatidylcholine (PC) had no effect. (132)
Stimulates Brain Dopamine
(PS) in Flavay Plus® restores your brain’s supply and output of dopamine—essential to memory, attention and problem-solving. Dopamine is also associated to the sense-of well-being, reward-behavior,
mood and bodily coordination.(128-133,331,332)
Phosphatidylserine restores dopamine release and benefits glutamatergic neurotransmission. Dopaminergic, glutamatergic and cholinergic neurotransmission play an important role in learning, memory and other cognitive functions. (133,299)
Persons diagnosed with clinical depression have shown marked improvement in their symptoms as a result of taking phosphatidylserine daily and this is likely connected to the finding that phosphatidylserine restores dopamine release. Reduced dopamine levels are also thought to contribute to attention deficit disorder and this natural substance has proven to be
an effective therapeutic agent for ADD and ADHD.(114, 128-133)
Normalizes Cortisol (Stress) and Speeds Recovery from Injury
(PS) in Flavay Plus® significantly inhibits ACTH and cortisol (stress-induced and exercise-induced hormones) in exercise. (134)
Following intense weight-training, cortisol was significantly lower in subjects taking phosphatidylserine. (121,144,145)
(PS) in Flavay Plus® can significantly increase time to exhaustion in cycling. (258)
A double-blind, placebo controlled study using 14 healthy and trained male athletes underwent cycling exercise prior to and following the supplementation period. Endurance was measured using a cycle ergometer at 85% VO2 max. After ten days, the group taking phosphatidylserine experienced about 30% more time before exhaustion, while the placebo group experienced no change. (258)
Phosphatidylserine is Important To Every Cell in Your Body
Phosphatidylserine is found in every cell in your body and the membrane proteins it activates are important in all your cells. Research shows phosphatidylserine is important to:
bone matrix formation,
beat coordination of the heart,
hormone secretion by the adrenal glands,
cell repair and removal by the immune system.(111,112)
Phosphatidylserine is necessary for transmission of information between your brain cells. (111,112)
Turn Back Brain-Aging with PhosphatidylSerine
Human clinical studies show phosphatidylserine may assist against the symptoms of dementia and
Age-Associated Memory Impairment (AAMI), also in reducing the risk of dementia and cognitive
Flavay Plus® (4 per day) for 12 weeks may result in reversal of brain-aging by nearly 14 years. (168, 126)
A reversal of brain-aging of nearly 14 years was shown after 12 weeks of
supplementation with 300 mg per day of phosphatidylserine. Improvements were found in
learning and remembering written information, remembering names and recognizing people, and memory of
Children and young adults also get results in maintaining a sharp mind and controlling stress. Studies show
students experience improved learning abilities and performance. Placebo-controlled and double-blind trials
show that young university students experience significantly less stress from tests, stay
more clear-headed and composed, and keep a more stable mood when taking phosphatidylserine. (125)
What is PhosphatidylSerine?
Phosphatidylserine is a phospholipid (a fatty molecule) which contains both amino and fatty acids.
Phosphatidylserine is found in every human cell and is universally present in living things from the most simple
to the most complex. Phosphatidylserine has many known functions throughout all our tissues and organs, and most importantly, our brain.
Phosphatidylserine is found mainly in the inner part of cell membranes where it acts as a signaling molecule and is involved in a number of enzymatic functions. While most tissues are no more than 3% phosphatidylserine, your brain and nerve cells are highly enriched with phosphatidlyserine, up to 18%. Nerve cells depend on phosphatidylserine for normal neuro-transmitter metabolism and nerve signal transmission. Maintaining brain levels of phosphatidylserine is associated to normal and efficient signal transduction processes, efficient glucose metabolism and healthy cognitive and mental functions. (291,336,337)
Phosphatidylserine supplementation is shown to improve a large number of cognitive functions, including memory, learning and attention, and reduction of stress.
Decades of research have established phosphatidylserine (derived from soy lecithin*) as the best single means for conserving memory and other
higher brain functions. Findings from controlled clinical trials show when intake of
phosphatidylserine is doubled, or better still quadrupled, as a dietary supplement, the majority of persons
derive measurable brain benefits. (211, 110)
A phosphorylated serine is available as a dietary supplement but does not substitute for
phosphatidyl serine (PS), despite the claims of its
manufacturer. Though it resembles the head piece, phosphorylated serine is
different—it is not a phospholipid and does not work like PS does.
Consumers report phosphorylated serine can cause highly uncomfortable adverse reactions. Be
sure you get the real thing.
Phosphatidylerine’s tails of amino and fatty acids, the extra negative
charge on its head piece and unique conformation are essential to its specific actions.
Phosphatidylserine in Flavay Plus® is extracted from soy which is confirmed non-GMO.
The phosphatidylserine in Flavay Plus® was the subject of many human clinical
trials regarding memory loss, mood, cognitive performance and learning ability.
The use of phosphatidylserine in Flavay Plus® is well validated through clinical
research and proven safe in standard toxicology tests.
The large number of human studies conducted on phosphatidylserine in Flavay Plus® produced a flawless safety record. First, it has proven compatible with a wide array of medications
including: antacids, anti-hypertensives, anti-inflammatories, anti-ulcer and mucolytic agents, diuretics,
anti-thrombotics, hypoglycemics, anti-arrhythmics, insulin, calcium channel blockers, calcitonin, chemotherapy
drugs and other prescription medications. Second, phosphatidylserine is well tolerated by elderly patients
with chronic diseases such as cerebrovascular, artery and vein disorders, heart diseases, high blood
pressure, diabetes, lung diseases, digestive system diseases and arthritis.
Interestingly, clinical researchers found phosphatidylserine lowered uric acid levels and liver SGPT in
their elderly patients—which can signify improved liver health. (106,110,114-117,119)
Not all phosphatidylserine products are equal. The marketplace is full of inferior variations of
scientifically-proven products. Those who are looking for proven results—and not just claimed or implied results—want the authentic products proven in
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* Results vary by person and are not guaranteed. NOTE: We do not compensate
for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments
from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.
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†These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.